1. What Cefodizime Sodium for injection is and what it is used for

Cefodizime Sodium for injection is Whitish or pale yellowish crystalline powder.
Cefodizime sodium is a broad-spectrum, third generation cephalosporin. It is highly resistant to a broad spectrum of beta-lactamases produced by most kinds of bacterium. Cefodizime sodium has antibacterial action to several kinds of gram-positive and gram-negative organisms. Cefodizime sodium has an immunomodulating activity, i.e. it can serve as a BRM to increase CD4 in the body, which enhances the CD4/CD8 ratio, leading to cooperative eradication of bacrteria. Bacteroides, Acinetobacter, Enterococcus faecalis, Listerella, mycoplasma, chlamydia are resistant to this drug.
The mechanism of Cefodizime sodium antibacterial action is inhibiting the biosynthesis of bacterial cell wall mucopeptides.

2. How to use Cefodizime Sodium for injection

INDICATIONS
Susceptible strains
Staphylococcus aureus (except MRSA), Streptococci (except Enterococci), Pneumococcus, Gonococcus (include the strain which can produce -lactamas), Diplococcus meningitides, Branhamella, Escherichia coli, Shigella, Serratia, Citrobacter spp., Klebsiella spp., Proteus spp., Providencia spp., Morganrlla spp., Hemophilus influenza, Corynebacterium
Uses
1. Infection of the Respiratory: Laryngopharyngitis, Acute bronchitis, Tonsillitis (peritonsillitis, peritonsillar abscess), Chronic bronchitis, Secondary infection of chronic respiratory disorder, Pneumonia, Pulmonary pyosis
2. Infection of Urogenital System: Pyelonephritis, Cystitis, Gonococcal urethritis, Uterine appendage inflammation, Intrauterine infection, Pelvic cavity inflammation, Parauterine inflammation, Bartholins adenitis
3. Infection of the liver and Biliary System: Cholangitis, Cholecystitis, Hepatic abscess
4. Abdominal Infection: Peritonitis (pelviperitonitis,abscess of cul de sac)
5. Infection of ear-nose-throat department: Otitis media, Sinusitis
6. Septicemia
7. Medullitis
ADMINISTRATION AND DOSAGE
Usage: intravenous injection, intravenous infusion, intramuscular injection.
Intravenous injection: 1.0g injection of cefodizime sodium dissolved in 4ml water for injection, within 3 to 5 minutes of injection.
Intravenous drip: 1.0g dissolved in 40ml water for injection, saline or Ringer39s injection of cefodizime sodium, 20 to 30 minutes of infusion.
Intramuscular injection: 1.0g injection of cefodizime sodium dissolved in 4ml water for injection, the gluteus deep injection; in order to prevent the pain, the product was dissolved in 1% injection of lidocaine solution (in this case the need to avoid intravascular injection)
Dosage:
Adults: Usual Dosage: 1~2g/day; Severe Infections: Dosage maybe increased to 4g/day.
Children:Usual Dosage: 60~80mg/kg/day; Severe Infections: Dosage maybe increased to 120mg/kg/day.

3. Possible side effects

Occasionally rash, urticaria, itching or fever may occur. Fever, cough, dyspnea, Anaemia, granulocytopenia, thrombocytopenia, eosinophilia may occur occasionally.Since shock may rarely occur, careful administration is required. In the event of symptom, therapy should be discontinued and appropriate measures are taken.

4. Storing Cefodizime Sodium for injection

Store in cool, well closed container (not more than 20).